Environmental Adversity and Increasing Genetic Risk for Externalizing Disorders

Environmental adversity and increasing genetic risk for externalizing disorders.

CONTEXT Studies of gene-environment interplay in the development of psychiatric and substance use disorders are rapidly accumulating. However, few attempts have been made to integrate findings and to articulate general mechanisms of gene-environment influence in the emergence of psychopathology. OBJECTIVE To identify patterns of gene-environment interplay between externalizing disorders (anti...

Behavioral disinhibition: liability for externalizing spectrum disorders and its genetic and environmental relation to response inhibition across adolescence.

Behavioral disinhibition has been characterized as a generalized vulnerability to externalizing disorders. Despite increasing evidence for its validity and heritability, the structural stability of behavioral disinhibition across adolescence and the strength and etiology of its relation to executive functions have not been studied. In this multivariate twin study, the authors assessed behaviora...

Family adversity, positive peer relationships, and children's externalizing behavior: a longitudinal perspective on risk and resilience.

Peer acceptance and friendships were examined as moderators in the link between family adversity and child externalizing behavioral problems. Data on family adversity (i.e., ecological disadvantage, violent marital conflict, and harsh discipline) and child temperament and social information processing were collected during home visits from 585 families with 5-year-old children. Children's peer ...

Current strategies for investigating the genetic and environmental risk factors for affective disorders.

The structure of genetic and environmental risk factors for anxiety disorders in men and women.

BACKGROUND The anxiety disorders exhibit high levels of lifetime comorbidity with one another. Understanding the underlying causes of this comorbidity can provide insight into the etiology of the disorders and inform classification and treatment. OBJECTIVE To explain anxiety disorder comorbidity by examining the structure of the underlying genetic and environmental risk factors. DESIGN Life...